A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation
JL Nosbisch, JE Bear, JM Haugh Journal of Biological Chemistry 298 (5) | 2022 |
| Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling A Chandra, MT Butler, JE Bear, JM Haugh Biophysical Journal 121 (1), 102-118 | 2022 |
| Microfluidic devices fitted with “flowver” paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration SA Baldwin, SM Van Bruggen, JM Koelbl, R Appalabhotla, JE Bear, Biomicrofluidics 15 (4), 044101 | 2021 |
Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling
SMT Rahman, W Zhou, A Deiters, JM Haugh Journal of Biological Chemistry 295 (25), 8494-8504 | 2020 |
| Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensingJL Nosbisch, A Rahman, K Mohan, TC Elston, JE Bear, JM Haugh PLOS Computational Biology 16 (4), e1007708 | 2020 |
| Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients CJ Miller, PK LaFosse, SB Asokan, JM Haugh, JE Bear, TC Elston Integrative Biology 11 (6), 280-292 | 2019 |
| Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation K Tiruthani, A Mischler, S Ahmed, J Mahinthakumar, JM Haugh, BM Rao Science signaling 12 (584), eaap7584 | 2019 |
| Lysophosphatidic acid provokes fibroblast chemotaxis through combinatorial regulation of myosin IISB Asokan, HE Johnson, J Sondek, MS Shutova, TM Svitkina, JM Haugh, bioRxiv, 355610 | 2019 |
| A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis K Mohan, JL Nosbisch, TC Elston, JE Bear, JM Haugh Biophysical Journal 113 (1), 185-194 | 2017 |
| Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation A Rahman, JM Haugh Journal of Biological Chemistry 292 (7), 2866-2872 | 2017 |
| Are Filopodia Privileged Signaling Structures in Migrating Cells? HE Johnson, JM Haugh Biophysical Journal 111 (9), 1827-1830 | 2016 |
| Lamellipodia are crucial for haptotactic sensing and response SJ King, SB Asokan, EM Haynes, SP Zimmerman, JD Rotty, JG Alb, J Cell Sci 129 (12), 2329-2342 | 2016 |
| Systems Cell Biology: An Overview DA Lauffenburger, JM Haugh, HM Byrne, R Linding Academic Press | 2016 |
| Quantitative analysis of B-lymphocyte migration directed by CXCL13 X Liu, SB Asokan, JE Bear, JM Haugh Integrative Biology 8 (8), 894-903 | 2016 |
| GMFβ controls branched actin content and lamellipodial retraction in fibroblasts EM Haynes, SB Asokan, SJ King, HE Johnson, JM Haugh, JE Bear Journal of Cell Biology 209 (6), 803-812 | 2015 |
| Linking morphodynamics and directional persistence of T lymphocyte migration X Liu, ES Welf, JM Haugh Journal of The Royal Society Interface 12 (106), 20141412 | 2015 |
| Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks LE Herring, KG Grant, K Blackburn, JM Haugh, MB Goshe Journal of Chromatography B 988, 166-174 | 2015 |
| F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling HE Johnson, SJ King, SB Asokan, JD Rotty, JE Bear, JM Haugh Journal of Cell Biology 208 (4), 443-455 | 2015 |
| Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and-independent pathways JD Rotty, C Wu, EM Haynes, C Suarez, JD Winkelman, HE Johnson, Developmental cell 32 (1), 54-67 | 2015 |
| Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway SB Asokan, HE Johnson, A Rahman, SJ King, JD Rotty, IP Lebedeva, Developmental cell 31 (6), 747-760 | 2014 |
